What is Glutathione Peroxidase?
Glutathione peroxidase is no other than the general name that does belong to the enzyme family that has peroxidase activity. Its main biological role is that of protecting an organism from getting any type of oxidative damage.
What the biochemical function of glutathione peroxidase is about is to help lessen lipid hydro peroxides to their corresponding alcohols. They also assist in reducing free hydrogen peroxide to water.
There is several isozymes that are encoded by varying types of genes. Glutathione peroxidase 1 is the most abundant of them all. It has a high preference for lipid hydro peroxides and can be found within the cytoplasm of almost all kinds of mammalian tissues.
The preferred substrate in this case is no other than hydrogen peroxide. Glutathone peroxidase is something that is expressed in almost all of mammalian cells. This is usually at much lower levels on the average.
Glutathione peroxidase is both an intestinal and extracellular form of enzyme. Glutathione peroxidate 3 is extracellular and is abundant in plasma. As of now, there are 8 different types of glutathione peroxidase, which have now been identified as being part of the human system.
These 8 forms of glutathione peroxidase are no other than the following. They are GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, and GPX8. Glutathione peroxidase was discovered back in 1957 by Gordon C. Mills.
Glutathione peroxidase or GPX for short is from an antioxidant family of enzymes. What this GPX does is to scavenge, as well as, inactivate both hydrogen and lipid type of peroxides.
This process is something that does help to protect the body against any form of oxidative stress of any kind.
Without a doubt, one of the most important of all antioxidant enzymes in humans, is no other than glutathione peroxidase. Despite the fact that GPX is a key antioxidant enzyme in description.
Glutathione peroxidase is an antioxidant enzyme that does indeed play its own crucial role in the human body. It is also an antioxidant that does function as being a free radical scavenger and does protect the body from any oxidation occurring.
GPX is something that can be found naturally in a wide variety of fruits and vegetables.
It contains the mineral called selenium, as well, in addition. As was previously mentioned here, and will be again, glutathione peroxidase has eight different family members.
These eight different family members, all do have, the very same form of special free radical scavenging function abilities.
These glutathione peroxidase family members are each tissue specific in their own ways. An example of this for instance is this, GPX1 is the most abundant of them all, and it is something that can be found in all the tissues of the human body.
Another example is this, and that is, GPX2 isn't at all like GPX1. It cannot be found in all the tissues that go throughout the human body. GPX2 can only be found mainly within the intestines.
If you want to take this a step further, GPX5 is a family member of glutathione peroxidase, which can be found in the tissues that are connected to the male reproductive tract. Another fact about GPX5 is this.
It is the very thing that does help to protect the delicate membranes that are associated with the spermatozoa or sperm. These very delicate membranes are totally secure from any form of oxidative damage that can be caused at the hand of lipid peroxidation.
It is the one thing that can promote sperm that are very healthy in detail.
When you make sure to increase your glutathione peroxidase levels. You are actually increasing the overall productivity of the GPX1 itself and vice versa. This is why it is very important to always make sure to eat a diet that is rich in antioxidants.
This can be achieved best by eating an assortment of varied fruits and vegetables on the average. What is highly advised to add to one's diet is organic and locally-grown fruits and vegetables.
These fruits and vegetables should be very rich in delivering GPX in a major way. Don't settle for anything less than that.
Glutathione peroxidase is the one and only enzyme that does help glutathione to lessen the presence of free radicals all together. Some of these free radicals do include lipid hydro peroxides and hydrogen peroxide.
What glutathione peroxidase does is to use glutathione to be the most ultimate of all electron donors in its own way.
This amazing electron donor has the power to quench out the free radicals and stop them from proving to be harmless to the human body in every way. It is the one thing, which does play a role, and this role is to become the catalyst for glutathione in the end.
GPX is an enzyme that has truly healthy and healing antioxidant properties all its own.
The brain is one part of the human body that is open and highly susceptible to free radical damage. This is the one reason why it is high in GPX activity on the average. The brain is, and will always be, the one major controller for the entire human system as a rule.
It can become vulnerable to not just free radicals, but also, all sorts of other invading things overall. The high GPX activity does indicate that glutathione peroxidase is standing guard over the brain and other parts of the human body.
GPX1, GPX2, GPX3, and GPX4 enzymes do contain the mineral selenium. It is selenium that is mainly responsible for doing away with the presence of any form of lipid damaging peroxides that can emerge. The selenium itself is the one component that makes glutathione peroxidase very strong.
This is because it knows firsthand how to destroy all forms of bad peroxide in the human body.
This destruction of these bad peroxides does ensure that the human body is protected in every way. This includes protecting its cells and membranes against any oxidative damage that can prove to be detrimental to the body.